BindingDB BDBM50429867 CHEMBL2333365

BDBM50429867 CHEMBL2333365

SMILES Cc1c(F)c(ccc1C(=O)N1CCOc2ccc(cc2C1)-c1ccc(N)nc1)S(C)(=O)=O

InChI Key InChIKey=LNFBAYSBVQBKFR-UHFFFAOYSA-N

Data 140 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50429867

Serine/threonine-protein kinase Nek7(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50429867(CHEMBL2333365)

IC50: >1.00E+4nMAssay Description:Inhibition of NEK7 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Filter my 140 hits

Targets 137▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2
- Protein kinase C beta type 2
- Mitogen-activated protein kinase 8 2
- Serine/threonine-protein kinase haspin 1
- Receptor tyrosine-protein kinase erbB-2 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- LIM domain kinase 1 1
- Hepatocyte growth factor receptor 1
- ALK tyrosine kinase receptor 1
- 5'-AMP-activated protein kinase subunit beta-1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Serine/threonine-protein kinase Nek7 1
- Glycogen synthase kinase-3 alpha 1
- Glycogen synthase kinase-3 beta 1
- Calcium/calmodulin-dependent protein kinase type 1 1
- Protein kinase C iota type 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Serine/threonine-protein kinase Nek2 1
- Cell division cycle 7-related protein kinase 1
- Protein kinase C theta type 1
- MAP kinase-interacting serine/threonine-protein kinase 2 1
- Serine/threonine-protein kinase PAK 3 1
- Serine/threonine-protein kinase PAK 6 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Tyrosine-protein kinase JAK2 1
- Serine/threonine-protein kinase 10 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Dual specificity mitogen-activated protein kinase kinase 4 1
- Tyrosine-protein kinase ZAP-70 1
- Serine/threonine-protein kinase Sgk2 1
- Serine/threonine-protein kinase Sgk1 1
- Serine/threonine-protein kinase Sgk3 1
- Ephrin type-A receptor 2 1
- Tyrosine-protein kinase ITK/TSK 1
- DNA-dependent protein kinase catalytic subunit 1
- Tyrosine-protein kinase receptor UFO 1
- Protein kinase C eta type 1
- Insulin-like growth factor 1 receptor 1
- Tyrosine-protein kinase Blk 1
- Receptor-interacting serine/threonine-protein kinase 2 1
- Epidermal growth factor receptor 1
- Homeodomain-interacting protein kinase 2 1
- Serine/threonine-protein kinase NLK 1
- Ribosomal protein S6 kinase beta-1 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Casein kinase I isoform delta 1
- Nuclear receptor subfamily 2 group C member 2 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Tyrosine-protein kinase Lyn 1
- Focal adhesion kinase 1 1
- Heat shock protein HSP 90-beta 1
- Serine/threonine-protein kinase 33 1
- Ephrin type-B receptor 1 1
- Activated CDC42 kinase 1 1
- MAP kinase-activated protein kinase 2 1
- MAP kinase-activated protein kinase 3 1
- Platelet-derived growth factor receptor beta 1
- MAP kinase-activated protein kinase 5 1
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 1
- Muscle, skeletal receptor tyrosine-protein kinase 1
- Death-associated protein kinase 2 1
- Serine/threonine-protein kinase D2 1
- Serine/threonine-protein kinase D1 1
- PAS domain-containing serine/threonine-protein kinase 1
- Death-associated protein kinase 3 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase TAO1 1
- Testis-specific serine/threonine-protein kinase 1 1
- Mitogen-activated protein kinase kinase kinase kinase 2 1
- Protein kinase C epsilon type 1
- Mast/stem cell growth factor receptor Kit 1
- Protein-tyrosine kinase 6 1
- Cyclin-dependent kinase 5 activator 1 1
- Mitogen-activated protein kinase kinase kinase 9 1
- Serine/threonine-protein kinase VRK2 1
- RAC-gamma serine/threonine-protein kinase 1
- Mitogen-activated protein kinase kinase kinase 5 1
- Interleukin-1 receptor-associated kinase 1 1
- Tyrosine-protein kinase ABL2 1
- Tyrosine-protein kinase ABL1 1
- RAC-alpha serine/threonine-protein kinase 1
- Rho-associated protein kinase 2 1
- cGMP-dependent protein kinase 1 1
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Rho-associated protein kinase 1 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Tyrosine-protein kinase Fes/Fps 1
- Serine/threonine-protein kinase ULK2 1
- Mitogen-activated protein kinase 1 1
- Discoidin domain-containing receptor 2 1
- Serine/threonine-protein kinase 4 1
- Protein kinase C delta type 1
- SRSF protein kinase 3 1
- G protein-coupled receptor kinase 5 1
- Dual specificity protein kinase CLK2 1
- Protein-tyrosine kinase 2-beta 1
- Tyrosine-protein kinase Mer 1
- Serine/threonine-protein kinase N2 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Ribosomal protein S6 kinase alpha-2 1
- Ribosomal protein S6 kinase alpha-3 1
- Ribosomal protein S6 kinase alpha-1 1
- Serine/threonine-protein kinase TBK1 1
- Fibroblast growth factor receptor 4 1
- Vascular endothelial growth factor receptor 2 1
- Tyrosine-protein kinase HCK 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 1 1
- Fibroblast growth factor receptor 2 1
- Fibroblast growth factor receptor 3 1
- Vascular endothelial growth factor receptor 1 1
- Serine/threonine-protein kinase PLK1 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Serine/threonine-protein kinase PLK3 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Tyrosine-protein kinase receptor TYRO3 1
- RAC-beta serine/threonine-protein kinase 1
- Mitogen-activated protein kinase 10 1
- Serine/threonine-protein kinase BRSK1 1
- Protein kinase C gamma type 1
- Misshapen-like kinase 1 1
- Tyrosine-protein kinase CSK 1
- Ribosomal protein S6 kinase alpha-6 1
- Protein kinase C alpha type 1
- Ribosomal protein S6 kinase alpha-5 1
- Protein kinase C zeta type 1
- Serine/threonine-protein kinase Chk2 1
- Serine/threonine-protein kinase MARK1 1
- Serine/threonine-protein kinase Chk1 1
- Tyrosine-protein kinase Yes 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 1
- Serine/threonine-protein kinase WNK2 1
- Serine/threonine-protein kinase STK11 1
Publications 1▿
- J Med Chem 56: 2218-34 (2013) 140
Institutions 1▿
- Exelixis 140
Affinity: 3.0E+3 to 1.0E+4 nM▿
- IC50 140
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1